A new facile synthesis of steroid dimers containing 17,170-dicarboxamide spacers

Carrilho, Rui M.B. and Pereira, Mariette M. and Moreno, Maria José S.M. and Takács, Attila and Kollár, László (2013) A new facile synthesis of steroid dimers containing 17,170-dicarboxamide spacers. TETRAHEDRON LETTERS, 54. pp. 2763-2765. ISSN 0040-4039

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Abstract

A set of new steroid dimers linked through ring D-ring D were synthesized via catalytic diaminocarbonylation of 17-iodo-5 alpha-androst-16-ene, in the presence of palladium-phosphine in situ catalysts and aliphatic or aromatic diamines as N-nucleophiles. The dimeric steroidal compounds containing 17,17'-dicarboxamide spacers were obtained through highly chemoselective reactions in good isolated yields and completely characterized by spectroscopic techniques.

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