REAL

Vortioxetine: a novel antidepressant for the treatment of major depressive disorder

Gonda, Xénia and Sharma, Samata R. and Tarazi, F. I. (2019) Vortioxetine: a novel antidepressant for the treatment of major depressive disorder. EXPERT OPINION IN DRUG DISCOVERY, 14 (1). pp. 81-89. ISSN 1746-0441

[img] Text
VortioxetineGondA2018.pdf - Published Version
Restricted to Repository staff only

Download (979kB)

Abstract

Introduction: Vortioxetine is a novel antidepressant drug approved for the treatment of major depressive disorder (MDD) in adults. It is formulated into tablets and has a dose range of 5–20 mg. The recommended starting dose is 10 mg administered orally once daily without the need for food. Areas covered: This review focuses on the preclinical and clinical discovery of vortioxetine. It analyzes the pharmacological, neurochemical, and behavioral mechanisms of the medication and how these contribute to its potential therapeutic advantages as described in published preclinical and clinical studies and product labels. Expert opinion: Vortioxetine displays high affinity for serotonin transporter (SERT), and serotonin 5-HT3, 5HT1A, 5HT7 receptors. Functional studies show that vortioxetine acts as a SERT blocker, a 5-HT3, 5-HT7 receptor antagonist, and a 5-HT1A receptor agonist. The drug is active in animal models predictive of antipsychotic and antidepressant activities and demonstrates procognitive effects in several animal models that assessed memory, cognition, and executive functions. Short- and long-term clinical trials demonstrated the clinical efficacy of vortioxetine in treating depressive symptoms and cognitive deficits in MDD patients. It also displays fairly benign safety and tolerability profiles. Vortioxetine’s unique psychopharmacological properties might contribute to an improved clinical outcome in MDD patient populations.

Item Type: Article
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
Depositing User: Dr Xenia Gonda
Date Deposited: 23 Sep 2019 16:13
Last Modified: 23 Sep 2019 16:13
URI: http://real.mtak.hu/id/eprint/100601

Actions (login required)

Edit Item Edit Item