Heparan sulfate proteoglycan (HSPG) can take part in cell division: inside and outside

Ughy, Bettina and Schmidthoffer, Ildikó and Szilák, László (2019) Heparan sulfate proteoglycan (HSPG) can take part in cell division: inside and outside. CELLULAR AND MOLECULAR LIFE SCIENCES, 76 (5). pp. 865-871. ISSN 1420-682X (print); 1420-9071 (online)

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Prior to the cytokinesis, the cell-matrix interactions should be disrupted, and the mitotic cells round up. Prerequisite of mitosis, the centrosomes duplicate, spindle fibers are generated and move away from each other to opposite sides of the cells marking the cell poles. Later, an invagination in the plasma membrane is formed a few minutes after anaphase. This furrow ingression is driven by a contractile actomyosin ring, whose assembly is regulated by RhoA GTPase. At the completion of cytokinesis, the two daughter cells are still connected by a thin intercellular bridge, which is subjected to abscission, as the terminal step of cytokinesis. Here, it is overviewed, how syndecan-4, a transmembrane, heparan sulfate proteoglycan, can contribute to these processes in a phosphorylation-dependent manner.

Item Type: Article
Uncontrolled Keywords: Mitotic rounding, Small GTPases, Microtubules, Midbody, Polyploidy, Protein phosphorylation, Tiam1, Dynamin, ESCRT
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia
R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: MTMT SWORD
Date Deposited: 25 Sep 2019 12:28
Last Modified: 25 Sep 2019 12:28

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