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Role of P2 receptors in normal brain development and in neurodevelopmental psychiatric disorders

Huang, Lumei and Otrokocsi, Lilla and Sperlágh, Beáta (2019) Role of P2 receptors in normal brain development and in neurodevelopmental psychiatric disorders. BRAIN RESEARCH BULLETIN, 151. pp. 55-64. ISSN 0361-9230

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Abstract

The purinergic signaling system, including P2 receptors, plays an important role in various central nervous system (CNS) disorders. Over the last few decades, a substantial amount of accumulated data suggest that most P2 receptor subtypes (P2 × 1, 2, 3, 4, 6, and 7, and P2Y1, 2, 6, 12, and 13) regulate neuronal/neuroglial developmental processes, such as proliferation, differentiation, migration of neuronal precursors, and neurite outgrowth. However, only a few of these subtypes (P2 × 2, P2 × 3, P2 × 4, P2 × 7, P2Y1, and P2Y2) have been investigated in the context of neurodevelopmental psychiatric disorders. The activation of these potential target receptors and their underlying mechanisms mainly influence the process of neuroinflammation. In particular, P2 receptor-mediated inflammatory cytokine release has been indicated to contribute to the complex mechanisms of a variety of CNS disorders. The released inflammatory cytokines could be utilized as biomarkers for neurodevelopmental and psychiatric disorders to improve the early diagnosis intervention, and prognosis. The population changes in gut microbiota after birth are closely linked to neurodevelopmental/neuropsychiatric disorders in later life; thus, the dynamic expression and function of P2 receptors on gut epithelial cells during disease processes indicate a novel avenue for the evaluation of disease progression and for the discovery of related therapeutic compounds.

Item Type: Article
Uncontrolled Keywords: ATP; P2 receptors; Development; Schizophrenia; Fetal alcohol spectrum disorder; Autism spectrum disorder; Neuroinflammation; Gut microbiota
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 29 Oct 2019 07:51
Last Modified: 29 Oct 2019 07:51
URI: http://real.mtak.hu/id/eprint/102708

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