Lipinski, Piotr F. J. and Szűcs, Edina and Jaronczyk, Malgorzata and Kosson, Piotr and Benyhe, Sándor (2019) Affinity of fentanyl and its derivatives for the sigma(1)-receptor. MEDCHEMCOMM, 10 (7). pp. 1187-1191. ISSN 2040-2503
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Official URL: http://doi.org/10.1039/c9md00222g
Abstract
Fentanyl and its 11 commercially available derivatives were investigated as to their affinity for the sigma(1) receptor. The parent compound is a rather poor binder (IC50 = 4973 nM), but its close derivatives (benzylfentanyl or p-fluorofentanyl) have submicromolar affinities. Modelling provides a structural basis for the observed trends in activity.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3011 Biochemistry / biokémia |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 22 Nov 2019 12:23 |
| Last Modified: | 22 Nov 2019 12:23 |
| URI: | http://real.mtak.hu/id/eprint/103633 |
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