Polymorphisms of TNF-alpha and LT-alpha genes in multiple myeloma

Kádár, Katalin and Kovács, Margit and Karádi, István and Melegh, Béla and Pocsai, Zsuzsa and Mikala, Gábor and Tordai, Attila and Szilágyi, Ágnes and Ádány, Róza and Füst, George and Várkonyi, Judit (2008) Polymorphisms of TNF-alpha and LT-alpha genes in multiple myeloma. LEUKEMIA RESEARCH, 32 (10). pp. 1499-1504. ISSN 0145-2126

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Abstract

Allelic distribution of -308 G>A (TNF 1/2) polymorphism of the TNF-alpha, and the +252 A>G promoter polymorphism of the LT-alpha gene, the 1267 A>G polymorphism of the HSP70-2 gene as well as the -429 T>C promoter polymorphism of the RAGE gene were tested in 94 MM cases and 141 controls. Significantly less MM patients than controls carried the TNF2 allele (p=0.018) and the TNF2-LTA 252G haplotype (p=0.025). The difference was, however, restricted to the females, as well as the relatively young (<69 years) subjects. By contrast, we did not find differences with the other SNPs tested.

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