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Pyrophosphate therapy prevents trauma-induced calcification in the mouse model of neurogenic heterotopic ossification

Tökési, Natália and Kozák, Eszter and Fülöp, Krisztina and Dedinszki, Dóra and Hegedüs, Nikolett and Király, Bálint and Szigeti, Krisztián and Ajtay, Kitti and Jakus, Zoltán and Pomozi, Viola and Váradi, András (2020) Pyrophosphate therapy prevents trauma-induced calcification in the mouse model of neurogenic heterotopic ossification. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. pp. 1-9. ISSN 1582-1838 (print); 1582-4934 (online)

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Abstract

Trauma-induced calcification is the pathological consequence of complex injuries which often affect the central nervous system and other parts of the body simultaneously. We demonstrated by an animal model recapitulating the calcification of the above condition that adrenaline transmits the stress signal of brain injury to the calcifying tissues. We have also found that although the level of plasma pyrophosphate, the endogenous inhibitor of calcification, was normal in calcifying animals, it could not counteract the acute calcification. However, externally added pyrophosphate inhibited calcification even when it was administered after the complex injuries. Our finding suggests a potentially powerful clinical intervention of calcification triggered by polytrauma injuries which has no effective treatment.

Item Type: Article
Uncontrolled Keywords: animal models; bone-brain-nervous system interactions; disorders of calcium/phosphate metabolism; intervention; preclinical studies
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában > R850-854 Experimental medicine / kisérleti orvostudomány
R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 15 Sep 2020 07:59
Last Modified: 15 Sep 2020 07:59
URI: http://real.mtak.hu/id/eprint/113226

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