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The effects of mutant Ras proteins on the cell signalome

Takács, Tamás and Kudlik, Gyöngyi and Kurilla, Anita and Szeder, Bálint and Buday, László and Vas, Virág (2020) The effects of mutant Ras proteins on the cell signalome. Cancer and Metastasis Reviews. ISSN 0167-7659

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Abstract

The genetic alterations in cancer cells are tightly linked to signaling pathway dysregulation. Ras is a key molecule that controls several tumorigenesis-related processes, and mutations in RAS genes often lead to unbiased intensification of signaling networks that fuel cancer progression. In this article, we review recent studies that describe mutant Ras-regulated signaling routes and their cross-talk. In addition to the two main Ras-driven signaling pathways, i.e., the RAF/MEK/ERK and PI3K/AKT/mTOR pathways, we have also collected emerging data showing the importance of Ras in other signaling pathways, including the RAC/PAK, RalGDS/Ral, and PKC/PLC signaling pathways. Moreover, microRNA-regulated Ras-associated signaling pathways are also discussed to highlight the importance of Ras regulation in cancer. Finally, emerging data show that the signal alterations in specific cell types, such as cancer stem cells, could promote cancer development. Therefore, we also cover the up-to-date findings related to Ras-regulated signal transduction in cancer stem cells. © 2020, The Author(s).

Item Type: Article
Additional Information: Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary Department of Medical Chemistry, Semmelweis University Medical School, Budapest, Hungary Export Date: 11 August 2020 CODEN: CMRED Correspondence Address: Vas, V.; Institute of Enzymology, Research Centre for Natural SciencesHungary; email: vas.virag@ttk.hu Funding details: Magyar Tudományos Akadémia, MTA Funding details: K 124045, HunProEx 2018-1.2.1-NKP-2018-00005, ANN 118119, FIEK_16-1-2016-0005 Funding text 1: Open access funding provided by ELKH Research Centre for Natural Sciences. This work was supported by the grants from the National Research, Development and Innovation Fund of Hungary (K 124045, FIEK_16-1-2016-0005, HunProEx 2018-1.2.1-NKP-2018-00005, L.B.) (ANN 118119, A.C) and the MedinProt Program of the Hungarian Academy of Sciences (L.B.). The work of V.V. was supported by a János Bolyai Research Scholarship of the Hungarian Academy of Sciences.
Uncontrolled Keywords: PHOSPHORYLATION; SIGNAL TRANSDUCTION; Tumorigenesis; Mutant Ras protein;
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3015 Molecular biology / molekuláris biológia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 24 Sep 2020 08:34
Last Modified: 24 Sep 2020 08:34
URI: http://real.mtak.hu/id/eprint/114388

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