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Hypertriglyceridemia-induced acute pancreatitis: A prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases

Mosztbacher, Dóra and Hanák, Lilla and Farkas, Nelli and Szentesi, Andrea and Mikó, Alexandra and Bajor, Judit and Sarlós, Patrícia and Czimmer, József and Vincze, Áron and Hegyi, Péter Jenő and Erőss, Bálint and Takács, Tamás and Czakó, László and Németh, Balázs Csaba and Izbéki, Ferenc and Halász, Adrienn and Gajdán, László and Hamvas, József and Papp, Mária and Földi, Ildikó and Fehér, Krisztina Eszter and Illés, Dóra and Gódi, Szilárd and Varga, Márta and Csefkó, Klára and Török, Imola and Farkas, Hunor Pál and Novák, János and Bod, Barnabás and Sümegi, János and Dubravcsik, Zsolt and Illés, Dóra and Gódi, Szilárd and Kui, Balázs and Márta, Katalin and Pécsi, Dániel and Varjú, Péter and Szakács, Zsolt and Darvasi, Erika and Párniczky, Andrea and Hegyi, Péter (2020) Hypertriglyceridemia-induced acute pancreatitis: A prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases. PANCREATOLOGY, 20 (4). pp. 608-616. ISSN 1424-3903 (print); 1424-3911 (online)

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Abstract

Background Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP). It has been shown that hypertriglyceridemia aggravates the severity and related complications of AP; however, detailed analyses of large cohorts are inadequate and contradictory. Our aim was to investigate the dose-dependent effect of hypertriglyceridemia on AP. Methods AP patients over 18 years old who underwent triglyceride measurement within the initial three days were included into our cohort analysis from a prospective international, multicenter AP registry operated by the Hungarian Pancreatic Study Group. Data on 716 AP cases were analyzed. Six groups were created based on the highest triglyceride level (<1.7 mmol/l, 1.7–2.19 mmol/l, 2.2–5.59 mmol/l, 5.6–11.29 mmol/l, 11.3–22.59 mmol/l, ≥22.6 mmol/l). Results Hypertriglyceridemia (≥1.7 mmol/l) presented in 30.6% of the patients and was significantly and dose-dependently associated with younger age and male gender. In 7.7% of AP cases, hypertriglyceridemia (≥11.3 mmol/l) was considered as a causative etiological factor; however, 43.6% of these cases were associated with other etiologies (alcohol and biliary). Hypertriglyceridemia was significantly and dose-dependently related to obesity and diabetes. The rates of local complications, organ failure and maximum CRP level were significantly and dose-dependently raised by hypertriglyceridemia. Triglyceride above 11.3 mmol/l was linked to a significantly higher incidence of moderately severe AP and longer hospital stay, whereas triglyceride over 22.6 mmol/l was significantly associated with severe AP as well. Conclusion Hypertriglyceridemia dose-dependently aggravates the severity and related complications of AP. Diagnostic workup for hypertriglyceridemia requires better awareness regardless of the etiology of AP.

Item Type: Article
Uncontrolled Keywords: Acute pancreatitis; Hypertriglyceridemia; Etiology; Cohort; Severity
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 06 Oct 2020 10:12
Last Modified: 24 Apr 2023 08:05
URI: http://real.mtak.hu/id/eprint/115740

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