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Effective natural food complements: anti-CoV-2 spike protein directed druggable inhibitors

Oláh, Zoltán and Ökrész, László and Török, Ibolya and Pestenácz, Anikó and Harkai, Anikó and Kocsis, Éva (2020) Effective natural food complements: anti-CoV-2 spike protein directed druggable inhibitors. ECOCYCLES, 6 (2). pp. 38-45. ISSN 2416-2140

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Abstract

There is a number of photosynthetically produced small molecules that have previously been validated through SARS-CoV spike protein interaction assays for selectivity and effectivity in our database. Our specialty database, the AVIRA-DB, has been built from scientific papers that published results regarding selective & effective CoV-2 spike protein binding inhibitors that prevent virus binding to the Angiotensin Converting Enzyme type 2 (ACE2). These data have been accumulated since 2003, the time of the first well documented coronavirus pandemic. To develop our anti-viral nutraceutical capsule we favoured small molecules (Mw <1000 Dalton) from edible plant parts that are enriched in experimentally evaluated coronavirus inhibitors. From this “AVIRA-DB” we screened for local culture varieties of vegetables and spices that are enriched in the anti-viral hits. Thus, AVIRA is the first knowledge-based nutraceutical composition that was validated by selective anti-CoV-2’s spike protein assays, performed in silico, -vitro & -vivo. From Chemo- & Bio-text-mined meta-data from literature and patents resulted in druggable flavonoids and flavonols, which were validated as anti-CoV-2 spike protein directed small molecules that are preventing the binding of the virus to ACE2.

Item Type: Article
Subjects: Q Science / természettudomány > QK Botany / növénytan
R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
R Medicine / orvostudomány > RM Therapeutics. Pharmacology / terápia, gyógyszertan
Depositing User: Dr. Tamas Komives
Date Deposited: 24 Nov 2020 14:12
Last Modified: 03 Apr 2023 07:04
URI: http://real.mtak.hu/id/eprint/117302

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