REAL

Paraneoplastic anti-NMDA receptor encephalitis in 1830?

Tényi, Dalma and Szűcs, Anna and Kovács, Norbert and Illés, Zsolt László and Janszky, József Vladimír (2020) Paraneoplastic anti-NMDA receptor encephalitis in 1830? NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 7 (6). ISSN 2332-7812

[img]
Preview
Text
2020_Paraneoplastic_e887.full.pdf

Download (478kB) | Preview

Abstract

Our aim was to identify patients with probable anti-NMDA receptor encephalitis among historical medical cases.A case report published in leading Hungarian-, German- and Italian-language medical journals in the early 1840s was revisited.In 1830, an 18-year-old, healthy woman suffered epileptic seizures, followed by a 6-day-long state characterized by catalepsy, unresponsiveness, motionless, and light breathing. Her symptoms regularly returned in the following 1.5 years. Meanwhile, a progressively growing huge abdominal tumor appeared. One day, she suddenly started vomiting a large amount of foul-smelling pus mixed with blood, accompanied by bone fragments. Pus mixed blood with some membranous substance was also evacuated through the anus and vagina. After this event, she completely recovered; 1.5 years later, she married and later gave birth to 3 healthy children. The patient remained healthy during the 11-year follow-up.We suggest that in the description of a paraneoplastic case, an anti-NMDA receptor encephalitis can be dated back as far as to the 19th century, with an especially rare type of resolution: the disappearance of the symptoms after the spontaneous elimination of an ovarian teratoma.

Item Type: Article
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 04 Jan 2021 15:09
Last Modified: 04 Jan 2021 15:09
URI: http://real.mtak.hu/id/eprint/119054

Actions (login required)

Edit Item Edit Item