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Neurovascular Inflammaging in Health and Disease

Mészáros, Ádám and Molnár, Kinga and Nógrádi, Bernát and Hernádi, Zsófia and Nyúl-Tóth, Ádám and Wilhelm, Imola and Krizbai, István A. (2020) Neurovascular Inflammaging in Health and Disease. CELLS, 9 (7). pp. 1-23. ISSN 2073-4409

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Abstract

Aging is characterized by a chronic low-grade sterile inflammation dubbed as inflammaging, which in part originates from accumulating cellular debris. These, acting as danger signals with many intrinsic factors such as cytokines, are sensed by a network of pattern recognition receptors and other cognate receptors, leading to the activation of inflammasomes. Due to the inflammasome activity-dependent increase in the levels of pro-inflammatory interleukins (IL-1 beta, IL-18), inflammation is initiated, resulting in tissue injury in various organs, the brain and the spinal cord included. Similarly, in age-related diseases of the central nervous system (CNS), inflammasome activation is a prominent moment, in which cells of the neurovascular unit occupy a significant position. In this review, we discuss the inflammatory changes in normal aging and summarize the current knowledge on the role of inflammasomes and contributing mechanisms in common CNS diseases, namely Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke, all of which occur more frequently with aging.

Item Type: Article
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 26 Jan 2021 07:41
Last Modified: 26 Jan 2021 07:41
URI: http://real.mtak.hu/id/eprint/119978

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