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Cerebrovascular Changes and Neurodegeneration Related to Hyperlipidemia: Characteristics of the Human ApoB-100 Transgenic Mice

Tóth, Erzsébet Melinda and Dukay, Brigitta and Hoyk, Zsófia and Sántha, Miklós (2020) Cerebrovascular Changes and Neurodegeneration Related to Hyperlipidemia: Characteristics of the Human ApoB-100 Transgenic Mice. CURRENT PHARMACEUTICAL DESIGN, 26 (13). pp. 1486-1494. ISSN 1381-6128

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Abstract

Serum lipid levels are closely related to the structure and function of blood vessels. Chronic hyperlipidemia may lead to damage in both the cardio- and the cerebrovascular systems. Vascular dysfunctions, including impairments of the blood-brain barrier, are known to be associated with neurodegenerative diseases. A growing number of evidence suggests that cardiovascular risk factors, such as hyperlipidemia, may increase the likelihood of developing dementia. Due to differences in lipoprotein metabolism, wild-type mice are protected against diet-induced hypercholesterolemia, and their serum lipid profile is different from that observed in humans. Therefore, several transgenic mouse models have been established to study the role of different apolipoproteins and their receptors in lipid metabolism, as well as the complications related to pathological lipoprotein levels. This mini-review will focus on a transgenic mouse model overexpressing an apolipoprotein, the human ApoB-100. We will discuss literature data and current advancements on the understanding of ApoB-100 induced cardio- and cerebrovascular lesions in order to demonstrate the involvement of this type of apolipoprotein in a wide range of pathologies, and a link between hyperlipidemia and neurodegeneration.

Item Type: Article
Uncontrolled Keywords: TRANSGENIC MICE; ATHEROSCLEROSIS; DEMENTIA; endothelial dysfunction; cerebrovascular disease; neurodegeneration; hyperlipidemia; Blood-brain barrier (BBB); ApoB-100 lipoprotein;
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 29 Jan 2021 11:14
Last Modified: 29 Jan 2021 11:14
URI: http://real.mtak.hu/id/eprint/120223

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