Kardos, Julianna and Héja, László and Simon, Ágnes and Jablonkai, István and Kovács, Richárd and Jemnitz, Katalin (2018) Copper signalling: causes and consequences. CELL COMMUNICATION AND SIGNALING, 16 (1). ISSN 1478-811X
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Abstract
Copper-containing enzymes perform fundamental functions by activating dioxygen (O-2) and therefore allowing chemical energy-transfer for aerobic metabolism. The copper-dependence of O-2 transport, metabolism and production of signalling molecules are supported by molecular systems that regulate and preserve tightly-bound static and weakly-bound dynamic cellular copper pools. Disruption of the reducing intracellular environment, characterized by glutathione shortage and ambient Cu(II) abundance drives oxidative stress and interferes with the bidirectional, copper-dependent communication between neurons and astrocytes, eventually leading to various brain disease forms. A deeper understanding of of the regulatory effects of copper on neuro-glia coupling via polyamine metabolism may reveal novel copper signalling functions and new directions for therapeutic intervention in brain disorders associated with aberrant copper metabolism.
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| Additional Information: | Journal Article; Review Funding Agency and Grant Number: [KMR_12-1-2012-0112 TRANSRAT]; [VEKOP-2.1.1-15-2016-00156]; [OTKA K124558] Funding text: This work was supported by grants KMR_12-1-2012-0112 TRANSRAT, VEKOP-2.1.1-15-2016-00156 and OTKA K124558. Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Budapest, 1117, Hungary Institute of Neurophysiology, Charité-Universitätsmedizin, Berlin, Germany Cited By :28 Export Date: 6 April 2021 Correspondence Address: Kardos, J.; Functional Pharmacology Research Group, Magyar Tudósok körútja 2, Hungary; email: kardos.julianna@ttk.mta.hu Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Budapest, 1117, Hungary Institute of Neurophysiology, Charité-Universitätsmedizin, Berlin, Germany Cited By :28 Export Date: 7 April 2021 Correspondence Address: Kardos, J.; Functional Pharmacology Research Group, Magyar Tudósok körútja 2, Hungary; email: kardos.julianna@ttk.mta.hu Functional Pharmacology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Budapest, 1117, Hungary Institute of Neurophysiology, Charité-Universitätsmedizin, Berlin, Germany Cited By :37 Export Date: 29 July 2021 Correspondence Address: Kardos, J.; Functional Pharmacology Research Group, Magyar Tudósok körútja 2, Hungary; email: kardos.julianna@ttk.mta.hu Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; captopril, 62571-86-2; clioquinol, 130-26-7, 8057-20-3; copper, 15158-11-9, 7440-50-8; disulfiram, 97-77-8; elesclomol, 488832-69-5; glutathione, 70-18-8; metformin, 1115-70-4, 657-24-9; penicillamine, 2219-30-9, 52-67-5; tetrathiomolybdic acid, 13718-35-9, 16330-92-0; trientine, 112-24-3, 38260-01-4; Copper Funding details: Hungarian Scientific Research Fund, OTKA, K124558 Funding text 1: This work was supported by grants KMR_12-1-2012-0112 TRANSRAT, VEKOP-2.1.1-15-2016-00156 and OTKA K124558. |
| Uncontrolled Keywords: | GSH; Redox disproportionation and speciation of copper; Dynamic copper pool; Copper-rich aggregates; GSSG ratio; Copper chelate therapy; Neuro-glia coupling; |
| Subjects: | Q Science / természettudomány > QD Chemistry / kémia > QD04 Organic chemistry / szerves kémia |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 28 Sep 2021 12:46 |
| Last Modified: | 28 Sep 2021 12:46 |
| URI: | http://real.mtak.hu/id/eprint/131093 |
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