The first Pd-catalyzed Buchwald–Hartwig aminations at C-2 or C-4 in the estrone series

Bacsa, Ildikó and Szemerédi, Dávid and Wölfling, János and Schneider, Gyula and Fekete, Lilla and Mernyák, Erzsébet (2018) The first Pd-catalyzed Buchwald–Hartwig aminations at C-2 or C-4 in the estrone series. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY. ISSN 1860-5397

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Abstract

facile Pd-catalyzed C(sp2)–N coupling to provide a range of 2- or 4-[(subst.)phenyl]amino-13α-estrone derivatives has been achieved under microwave irradiation. The reactions were mediated with the use of Pd(OAc)2 as a catalyst and KOt-Bu as a base in the presence of X-Phos as a ligand. The desired products have been obtained in good to excellent yields. The nature and the position of the aniline substituent at the aromatic ring influenced the outcome of the couplings. 2-Amino-13α-estrone was also synthesized in a two-step protocol including an amination of 2-bromo-13α-estrone 3-benzyl ether with benzophenone imine and subsequent hydrogenolysis.

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