Járvás, Gábor and Szigeti, Márton and Campbell, Matthew P. and Guttman, András (2021) Chapter 19 - Database search assisted N-glycan structure identification. In: Carbohydrate Analysis by Modern Liquid Phase Separation Techniques (Second Edition). Elsevier, pp. 843-858.
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Abstract
Capillary electrophoresis-based glycan separation and structure identification is one of the most frequently used tools in almost all fields of biological-medical research and biopharmaceutical manufacturing. In this chapter, recent advances in database search assisted glycan structure identification techniques are discussed. The underlying theory together with the principles of the different approaches as well as practical aspects are described in detail targeting both academic and industrial audience. Methods, such as traditional glucose unit calculation, the so-called virtual ladder approach, exoglycosidase based glycan sequencing, as well as possible utilization options of the current databases are detailed emphasizing their fundamentals and applications.
Item Type: | Book Section |
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Subjects: | Q Science / természettudomány > QD Chemistry / kémia > QD01 Analytical chemistry / analitikai kémia |
Depositing User: | László Hajba |
Date Deposited: | 30 Sep 2021 08:02 |
Last Modified: | 30 Sep 2021 08:02 |
URI: | http://real.mtak.hu/id/eprint/131583 |
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