SZABADGYÖK-KUTATÁS ÉVTIZEDEI A szabadgyök kutatás harminc éve a Szent István Egyetem Takarmányozástani Tanszékén: szeléntől a mikotoxinokig = Thirty years of free radical research in the Animal Feeding Department at the Szent István University

Balogh, Krisztián and Erdélyi, Márta and Mézes, Miklós (2018) SZABADGYÖK-KUTATÁS ÉVTIZEDEI A szabadgyök kutatás harminc éve a Szent István Egyetem Takarmányozástani Tanszékén: szeléntől a mikotoxinokig = Thirty years of free radical research in the Animal Feeding Department at the Szent István University. Kaleidoscope history, 9 (16). pp. 202-211. ISSN 20622597

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Abstract

Free radical research started more than 30 years ago at our Department. At the beginning effects of oxidative stress was investigated in physiological and pathophysiological processes of rabbits, poultry and fish. Other studies with poultry targeted the investigation of selenium toxicosis and a correlation was found between selenium toxicosis and amount/activity of the glutathione redox system. Environmental induction models were developed for the investigation of factors affecting gene expression and activity of glutathione peroxidase. It was found that selenium supplementation increased the gene expression without correlation with enzyme activity in the same model. Results of recent research revealed that nano-selenium increases the amount of some antioxidant enzymes, out of the classic antioxidant defence. Our experiments aimed if mycotoxins induced oxidative stress directly or indirectly through damage of the antioxidant defence. Our investigations were based on the hierarchical model of oxidative stress, which propose that mild oxidative stress activates the gene expression of antioxidant enzymes. Our results suggested that activation of antioxidant gene expression occurs over a critical level of oxygen free radicals, without correlation with enzyme activity, for instance glutathione peroxidase, possibly due to the post-translation modification of enzyme protein.

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