REAL

Detection of non-polio and polio enteroviruses in Acute Flaccid Paralysis surveillance in Turkey

Korukluoglu, Gulay and Ozdemirer, Umit and Bayrakdar, Fatma and Unal, Zehra and Cosgun, Yasemin and Atak, Tunca and Karademirtok, Hulya and Ata, Isil and Kara, Fatih (2021) Detection of non-polio and polio enteroviruses in Acute Flaccid Paralysis surveillance in Turkey. ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 68 (2). pp. 92-98. ISSN 1217-8950

[img]
Preview
Text
article-p92.pdf

Download (1MB) | Preview

Abstract

Poliomyelitis was a disease feared worldwide, striking suddenly and paralysing mainly children for life. Monitoring of suspected cases of poliomyelitis is carried out with Acute Flaccid Paralysis (AFP) surveillance in Turkey. This study examines national data of AFP surveillance and the epidemiology of enteroviruses (EV) in Turkey from 2000 to 2019 and gives an overview of the detected serotypes of EVs. A total of 13,640 samples collected from patients with 5216 AFP pre-diagnosed cases (2 samples from each patient) and 3,208 contacts, during a 20-year period (2000-2019) were investigated. All isolated polioviruses were tested for their wild or vaccine origin according to the WHO recommended protocol by PCR and sequencing analysis were performed. Enterovirus positivity was detected in a total of 915 cases, which were identified as 204 Sabin-like polio virus (SLPV) and 711 non-polio enterovirus (NPEV). Of the 204 SLPV, 141 (69.1%) AFP were detected in patients and 63 (30.9%) were detected in samples taken from their contacts. Of the 711 NPEVs, 516 (72.5%) were from AFP cases and 195 (27.5%) were detected in samples taken from their contacts. It is concluded that the reason for the higher detection rate of NPEV in samples from AFP pre-diagnosed cases is attributed to the polio vaccination rates reaching 97% between 2008 and 2019 in Turkey. The most frequently detected NPEV serotypes were Coxackie A24, B3, and Echo 30. This retrospective study is the first comprehensive study in Turkey to evaluate the results of the AFP surveillance in the last 20 years.

Item Type: Article
Uncontrolled Keywords: immunology; SURVEILLANCE; myocarditis; Enteroviruses; polio virus; COXSACKIEVIRUS B3 SEQUENCES;
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 18 Oct 2021 05:59
Last Modified: 30 Jun 2022 23:15
URI: http://real.mtak.hu/id/eprint/132601

Actions (login required)

Edit Item Edit Item