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Epidemiology and antibiotic resistance profile of bacterial meningitis in Morocco from 2015 to 2018

Ikken, Youssef and Charof, Reda and Benaouda, Amina and Hilali, Farida and Akkaoui, Sanae and Elouennass, Mostafa and Sekhsokh, Yassine (2020) Epidemiology and antibiotic resistance profile of bacterial meningitis in Morocco from 2015 to 2018. ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 67 (4). pp. 243-251. ISSN 1217-8950

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Abstract

Over a 4-year study period from 2015 to 2018, altogether 183 isolates of bacterial meningitis were collected from 12 hospitals covering the entire Moroccan territory. Neisseria meningitidis represented 58.5%, Streptococcus pneumoniae 35.5%, and Haemophilus influenzae type b 6%. H. influenzae type b mainly affected 5-year-olds and unvaccinated adults. N. meningitidis serogroup B represented 90.7% followed by serogroup W135 with 6.5%. Decreased susceptibility to penicillin G (DSPG) for all isolates accounted for 15.7%, with 11.6% being resistant to penicillin G (PG) and 4.1% decreased susceptibility. Cumulative results of all strains showed 2.7% decreased susceptibility to amoxicillin and 3.3% resistant, 2.2% of isolates were resistant to third-generation cephalosporin and 2.2% were decreased susceptible, 5.5% were resistant to chloramphenicol and 2.7% were resistant to rifampin. The frequency of DSPG observed in our study is more common in S. pneumoniae than in N. meningitidis (P < 0.05). These isolates have been found to be highly susceptible to antibiotics used for treatment and prophylaxis chemotherapy and the observed resistance remains rare. The impact of introduction of conjugate vaccines against H. influenzae type b and S. pneumoniae (PCVs) is an advantage in reducing meningitis cases due to these two species. © 2020 Akademiai Kiado, Budapest.

Item Type: Article
Uncontrolled Keywords: Adult; Adolescent; Female; Male; ARTICLE; human; Child; major clinical study; controlled study; nonhuman; multicenter study; drug efficacy; minimum inhibitory concentration; Tetracycline; penicillin G; oxacillin; ciprofloxacin; ceftriaxone; vancomycin; CEFOTAXIME; NORFLOXACIN; vaccination; vaccination; Antibiotic Prophylaxis; serotype; amoxicillin; erythromycin; ampicillin; antibiotic sensitivity; rifampicin; cotrimoxazole; cephalosporin; Antibiotic resistance; levofloxacin; chloramphenicol; chemoprophylaxis; Streptococcus pneumoniae; Streptococcus pneumoniae; Haemophilus influenzae; bacterium isolate; ANTIMICROBIAL RESISTANCE; penicillin resistance; Neisseria meningitidis; Neisseria meningitidis; bacterial meningitis; MOROCCO; cephalosporin resistance; chloramphenicol resistance; Haemophilus influenzae type b; Co-resistance; Epidemiology meningitis; Haemophilus influenzae type b vaccine; Haemophilus meningitis;
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 27 Oct 2021 07:16
Last Modified: 31 Dec 2021 00:16
URI: http://real.mtak.hu/id/eprint/133090

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