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Fast 3 T nigral hyperintensity magnetic resonance imaging in Parkinson's disease

Hernádi, Gabriella and Pintér, Dávid and Nagy, Szilvia Anett and Orsi, Gergely and Komoly, Sámuel and Janszky, József Vladimír and Kovács, Norbert and Perlaki, Gábor (2021) Fast 3 T nigral hyperintensity magnetic resonance imaging in Parkinson's disease. SCIENTIFIC REPORTS, 11 (1). ISSN 2045-2322

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Abstract

The absence of nigral hyperintensity is a promising MR marker for Parkinson's disease (PD), but its small size imposes limitations on its routine use. Our aim was to compare Multi Echo Data Image Combination (MEDIC), segmented echo-planar imaging (EPISEG) and fluid-attenuated inversion recovery (FLAIR) sequences, as well as both magnitude (MAG) and susceptibility-weighted imaging (SWI) reconstructions of single-echo gradient echo for nigral hyperintensity imaging. Twenty-five healthy and twenty PD subjects were included. Sensitivity to motion artefacts, confidence of the radiologist in interpretation, rate of nondiagnostic scans and diagnostic accuracy were assessed. EPISEG was less motion-sensitive than MEDIC, MAG, and SWI, while FLAIR was less motion-sensitive than MAG and SWI. The reviewers were more confident when using EPISEG compared to any other techniques and MEDIC was superior to FLAIR. The proportions of nondiagnostic scans were lower for EPISEG than for other sequences. The best diagnostic performance was achieved for EPISEG (sensitivity = 65%, specificity = 96%). Using EPISEG, the absence of nigral hyperintensity in PD was associated with higher Hoehn-Yahr stage and MDS-UPDRS II + III. Nigral hyperintensity may be intact at the very early stages of PD. The promising properties of EPISEG may help the transfer of nigral hyperintensity imaging into daily clinical practice.

Item Type: Article
Additional Information: Export Date: 25 January 2021 Pecs Diagnostic Centre, Pecs, Hungary Department of Neurology, Medical School, University of Pecs, Pecs, Hungary MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary Neurobiology of Stress Research Group, Szentagothai Research Center, University of Pecs, Pecs, Hungary Department of Laboratory Medicine, Medical School, University of Pecs, Pecs, Hungary Export Date: 3 February 2021 Correspondence Address: Perlaki, G.; Pecs Diagnostic CentreHungary; email: petzinger.gabor@gmail.com Pecs Diagnostic Centre, Pecs, Hungary Department of Neurology, Medical School, University of Pecs, Pecs, Hungary MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary Neurobiology of Stress Research Group, Szentagothai Research Center, University of Pecs, Pecs, Hungary Department of Laboratory Medicine, Medical School, University of Pecs, Pecs, Hungary Export Date: 11 March 2021 Correspondence Address: Perlaki, G.; Pecs Diagnostic CentreHungary; email: petzinger.gabor@gmail.com Funding Agency and Grant Number: Hungarian Brain Research Program [2017-1.2.1-NKP-2017-00002, EFOP-3.6.2-16-2017-00008, NKFIH SNN125143, EFOP-3.6.1-16-2016-00004]; Higher Education Institutional Excellence Program I-II of the Ministry of Human Capacities in Hungary, within University of Pecs, Hungary [20765/3/2018/FEKUSTRAT]; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences; New National Excellence Program of the Ministry for Innovation and Technology [uNKP-19-4-PTE-122, uNKP-20-5-PTE-715]; [PTE aOK-KA-2017-05]; [PTE aOK-KA-2020-08] Funding text: Our study was supported by the Hungarian Brain Research Program (2017-1.2.1-NKP-2017-00002), EFOP-3.6.2-16-2017-00008 "The role of neuro-inflammation in neurodegeneration: from molecules to clinics", NKFIH SNN125143, EFOP-3.6.1-16-2016-00004 and Higher Education Institutional Excellence Program I-II of the Ministry of Human Capacities in Hungary, within the framework of the 5th thematic program of the University of Pecs, Hungary (20765/3/2018/FEKUSTRAT, FIKP II). PG was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences, uNKP-19-4-PTE-122 New National Excellence Program of the Ministry for Innovation and Technology and PTE aOK-KA-2017-05. SAN was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences, uNKP-20-5-PTE-715 New National Excellence Program of the Ministry for Innovation and Technology and PTE aOK-KA-2020-08. Pecs Diagnostic Centre, Pecs, Hungary Department of Neurology, Medical School, University of Pecs, Pecs, Hungary MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary Neurobiology of Stress Research Group, Szentagothai Research Center, University of Pecs, Pecs, Hungary Department of Laboratory Medicine, Medical School, University of Pecs, Pecs, Hungary Export Date: 9 June 2021 Correspondence Address: Perlaki, G.; Pecs Diagnostic CentreHungary; email: petzinger.gabor@gmail.com Pecs Diagnostic Centre, Pecs, Hungary Department of Neurology, Medical School, University of Pecs, Pecs, Hungary MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary Neurobiology of Stress Research Group, Szentagothai Research Center, University of Pecs, Pecs, Hungary Department of Laboratory Medicine, Medical School, University of Pecs, Pecs, Hungary Export Date: 10 September 2021 Correspondence Address: Perlaki, G.; Pecs Diagnostic CentreHungary; email: petzinger.gabor@gmail.com Pecs Diagnostic Centre, Pecs, Hungary Department of Neurology, Medical School, University of Pecs, Pecs, Hungary MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary Neurobiology of Stress Research Group, Szentagothai Research Center, University of Pecs, Pecs, Hungary Department of Laboratory Medicine, Medical School, University of Pecs, Pecs, Hungary Export Date: 13 September 2021 Correspondence Address: Perlaki, G.; Pecs Diagnostic CentreHungary; email: petzinger.gabor@gmail.com Pecs Diagnostic Centre, Pecs, Hungary Department of Neurology, Medical School, University of Pecs, Pecs, Hungary MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary Neurobiology of Stress Research Group, Szentagothai Research Center, University of Pecs, Pecs, Hungary Department of Laboratory Medicine, Medical School, University of Pecs, Pecs, Hungary Export Date: 14 September 2021 Correspondence Address: Perlaki, G.; Pecs Diagnostic CentreHungary; email: petzinger.gabor@gmail.com
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 28 Dec 2021 17:43
Last Modified: 23 Mar 2022 09:15
URI: http://real.mtak.hu/id/eprint/135045

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