REAL

The interplay between pathogens and Atg8 family proteins: thousand-faced interactions

Tóth, Dávid and Horváth V., Gábor and Juhász, Gábor (2021) The interplay between pathogens and Atg8 family proteins: thousand-faced interactions. FEBS OPEN BIO, 11 (12). pp. 3237-3252. ISSN 2211-5463

[img]
Preview
Text
TothFebs.pdf
Available under License Creative Commons Attribution.

Download (8MB) | Preview

Abstract

Autophagy is an intracellular degradation and recycling process that can also remove pathogenic intracellular bacteria and viruses from within cells (referred to as xenophagy) and activate the adaptive immune responses. But autophagy - especially Atg proteins including Atg8 family members - can also have proviral and probacterial effects. In this review, we summarize known interactions of bacterial, parasitic and viral proteins with Atg8 family proteins and the outcome of these interactions on pathogen replication, autophagy or mitophagy. We discuss the value of prediction software and the research methodology in the study of pathogen protein-Atg8 family protein interactions, with selected examples of potential LIR motif-containing SARS-CoV-2 proteins.

Item Type: Article
Uncontrolled Keywords: LC3; GABARAP; LIR motif; SARS-CoV-2; hfAIM; iLIR;
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia
Q Science / természettudomány > QH Natural history / természetrajz > QH426 Genetics / genetika, örökléstan
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 07 Feb 2022 09:10
Last Modified: 07 Feb 2022 09:10
URI: http://real.mtak.hu/id/eprint/137484

Actions (login required)

Edit Item Edit Item