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Network strategies to understand the aging process and help age-related drug design

Simkó, G. I. and Gyurkó, D. and Veres, D. V. and Nánási, Tibor and Csermely, Péter (2009) Network strategies to understand the aging process and help age-related drug design. GENOME MEDICINE: MEDICINE IN THE POST-GENOMIC ERA, 1 (9). p. 90. ISSN 1756-994X

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Abstract

Abstract Recent studies have demonstrated that network approaches are highly appropriate tools for understanding the extreme complexity of the aging process. Moreover, the generality of the network concept helps to define and study the aging of technological and social networks and ecosystems, which may generate novel concepts for curing age-related diseases. The current review focuses on the role of protein-protein interaction networks (interactomes) in aging. Hubs and inter-modular elements of both interactomes and signaling networks are key regulators of the aging process. Aging induces an increase in the permeability of several cellular compartments, such as the cell nucleus, introducing gross changes in the representation of network structures. The large overlap between aging genes and genes of age-related major diseases makes drugs that aid healthy aging promising candidates for the prevention and treatment of age-related diseases, such as cancer, atherosclerosis, diabetes and neurodegenerative disorders. We also discuss a number of possible research options to further explore the potential of the network concept in this important field, and show that multi-target drugs (representing ‘magic-buckshots’ instead of the traditional ‘magic bullets’) may become an especially useful class of age-related drugs in the future.

Item Type: Article
Uncontrolled Keywords: drug design
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3011 Biochemistry / biokémia
R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 11 Aug 2014 09:20
Last Modified: 11 Aug 2014 09:20
URI: http://real.mtak.hu/id/eprint/14150

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