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Fecal microbiota transplantation for recurrent Clostridioides difficile infection in patients with concurrent ulcerative colitis

Gholam-Mostafaei, Fahimeh Sadat and Yadegar, Abbas and Aghdaei, Hamid Asadzadeh and Shahrokh, Shabnam and Daryani, Nasser Ebrahimi and Zali, Mohammad Reza (2021) Fecal microbiota transplantation for recurrent Clostridioides difficile infection in patients with concurrent ulcerative colitis. ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 68 (4). pp. 279-285. ISSN 1217-8950

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Abstract

Treatment of recurrent Clostridioides difficile infection (rCDI) has emerged as an important management dilemma particularly in patients with underlying inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) has been used as a safe and highly effective treatment option for rCDI refractory to standard antibiotic therapies. The aim of this study was to report the efficacy of FMT in Iranian rCDI patients with concurrent IBD. A total of seven consecutive patients with ulcerative colitis (UC) who had experienced 3 episodes of rCDI were enrolled in this study. All patients received at least a single FMT administered during colonoscopy by direct infusion of minimally processed donor stool. Patients were followed for a minimum of 6 months for assessment of treatment efficacy and adverse events (AEs) attributable to FMT. All 7 UC patients (100%) experienced a durable clinical response to a single FMT following 2 months after the procedure. One patient received a second FMT in which a successful resolution of rCDI was ultimately achieved. No serious AEs from FMT were noted. FMT through colonoscopy was a safe, simple and effective alternative treatment approach for rCDI in patients with underlying IBD. However, its use and efficacy should be pursued in long-term prospective controlled trials.

Item Type: Article
Additional Information: Funding Agency and Grant Number: Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran [RIGLD 1061] Funding text: The authors are grateful to Dr. Colleen R. Kelly from Alpert Medical School of Brown University for her scientific comments and English revision. This study was supported financially by a grant [no. RIGLD 1061] from Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Uncontrolled Keywords: immunology; Inflammatory bowel disease; PREVENTION; GUIDELINES; recurrent infection; Intestinal microbiota; FECAL MICROBIOTA TRANSPLANTATION; Clostridioides difficile infection; bacteriotherapy;
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 20 Jul 2022 06:05
Last Modified: 31 Dec 2022 00:16
URI: http://real.mtak.hu/id/eprint/144964

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