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The role of microbiota and immune system crosstalk in cancer development and therapy

Behrouzi, Ava and Katebi, Asal and Riazi-Rad, Farhad and Mazaheri, Hoora and Ajdary, Soheila (2022) The role of microbiota and immune system crosstalk in cancer development and therapy. ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 69 (1). pp. 1-12. ISSN 1217-8950

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Abstract

Cancer is a multifactorial disease that is the second leading cause of death after cardiovascular disease in the world. In recent years, microbiota's role in the regulation and homeostasis of the immune system has been considered. Moreover, the immune system can affect the microbiota content. These interactions are critical to the functioning of the immune system. Numerous studies in animal and human models have shown the association of changes in microbiota components with the formation of an inhibitory microenvironment in the tumor and its escape from the immune system. Microbiota also plays a crucial role in the success of various anti-tumor treatments, and its modification leads to success in cancer treatment. The success of anti-tumor therapies that directly target the immune system, such as immune checkpoint blockade and T cell therapy, is also affected by the patient's microbiota composition. It seems that in addition to examining the patient's genetics, precision medicine should pay attention to the patient's microbiota in choosing the appropriate treatment method, and together with usual anti-tumor therapies, microbiota may be modified. This review discusses various aspects of the relationship between microbiota and anti-tumor immunity and its successful treatment.

Item Type: Article
Additional Information: Erratum: ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 69 (1). p. 87. DOI: http://doi.org/10.1556/030.2022.11650
Uncontrolled Keywords: Inflammation; CELL; CANCER; immunology; TRANSPLANTATION; EFFICACY; immune system; cancer therapy; Progression; LACTIC-ACID; Microbiota; gut microbiota; Intestinal microbiota; dysbiosis; PROBIOTIC BACILLUS-POLYFERMENTICUS;
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 21 Jul 2022 06:02
Last Modified: 22 Aug 2022 08:24
URI: http://real.mtak.hu/id/eprint/145024

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