Cancer Susceptibility as a Cost of Reproduction and Contributor to Life History Evolution

Dujon, Antoine M. and Boutry, Justine and Tissot, Sophie and Lemaître, Jean-François and Boddy, Amy M. and Gérard, Anne-Lise and Alvergne, Alexandra and Arnal, Audrey and Vincze, Orsolya and Nicolas, Delphine and Giraudeau, Mathieu and Telonis-Scott, Marina and Schultz, Aaron and Pujol, Pascal and Biro, Peter A. and Beckmann, Christa and Hamede, Rodrigo and Roche, Benjamin and Ujvari, Beata and Thomas, Frédéric (2022) Cancer Susceptibility as a Cost of Reproduction and Contributor to Life History Evolution. FRONTIERS IN ECOLOGY AND EVOLUTION, 10. ISSN 2296-701X

Preview

Text 2022_Dujon_et_al.pdf Available under License Creative Commons Attribution. Download (2MB) | Preview

Abstract

Reproduction is one of the most energetically demanding life-history stages. As a result, breeding individuals often experience trade-offs, where energy is diverted away from maintenance (cell repair, immune function) toward reproduction. While it is increasingly acknowledged that oncogenic processes are omnipresent, evolving and opportunistic entities in the bodies of metazoans, the associations among reproductive activities, energy expenditure, and the dynamics of malignant cells have rarely been studied. Here, we review the diverse ways in which age-specific reproductive performance (e.g., reproductive aging patterns) and cancer risks throughout the life course may be linked via trade-offs or other mechanisms, as well as discuss situations where trade-offs may not exist. We argue that the interactions between host–oncogenic processes should play a significant role in life-history theory, and suggest some avenues for future research.

Actions (login required)

Edit Item