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Factor XIII and inflammatory cells

Bagoly, Zsuzsa and Katona, Eva and Muszbek, László (2012) Factor XIII and inflammatory cells. Thrombosis Research, 129 Su. S77-81. ISSN 0049-3848, ESSN: 1879-2472

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Abstract

Factor XIII is a coagulation factor with multiple plasmatic and cellular functions part of which is outside of the field of traditional hemostasis. The aim of the review is to provide a brief summary on the relationship between coagulation factor XIII (FXIII) and the cells of the immune system. In the first part the structure and biochemical functions of plasma and cellular FXIII are briefly summarized. Then, the interaction between leukocytes and factor XIII is discussed. This part includes the activation of FXIII by human neutrophil elastase, the down-regulation of activated FXIII (FXIIIa) by granulocyte proteases within the clot, and the effect of FXIIIa on leukocytes. In the following part data on the expression and subcellular distribution of FXIII in monocytes/macrophages are summarized. Another part of the review is devoted to changes of FXIII expression during monocyte differentiation and monocyte activation by the classical or the alternative pathway. In the final part reports on the possible functions of cellular FXIII in monocytes and macrophages are evaluated.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
R Medicine / orvostudomány > RC Internal medicine / belgyógyászat
R Medicine / orvostudomány > RZ Other systems of medicine / orvostudomány egyéb területei
Depositing User: Dr. Zsuzsa Bagoly
Date Deposited: 23 Sep 2014 15:16
Last Modified: 23 Sep 2014 15:16
URI: http://real.mtak.hu/id/eprint/16228

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