Regulatory Networks Contributing to Psoriasis Susceptibility

Szabó, Kornélia and Bata-Csorgo, Zsuzsanna and Dallos, Attila and Bebes, Attila and Francziszti, László and Dobozy, Attila and Kemény, Lajos and Széll, Márta (2014) Regulatory Networks Contributing to Psoriasis Susceptibility. Acta dermato-venereologica, 94 (4). pp. 380-385. ISSN 1651-2057

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Abstract

The non-involved, healthy-looking skin of psoriatic pa- tients displays inherent characteristics that make it pro- ne to develop typical psoriatic symptoms. Our primary aim was to identify genes and proteins that are diffe- rentially regulated in the non-involved psoriatic and the normal epidermis, and to discover regulatory networks responsible for these differences. A cDNA microarray ex- periment was performed to compare the gene expression proiles of 4 healthy and 4 psoriatic non-involved epider- mis samples in response to T-cell lymphokine induction in organotypic cultures. We identiied 61 annotated genes and another 11 expressed transcripts that were differen- tially regulated in the psoriatic tissues. Bioinformatics analysis suggested that the regulation of cell morpholo- gy, development and cell death is abnormal, and that the metabolism of small molecules and lipids is differentially regulated in psoriatic epidermis. Our results indicate that one of the early steps of psoriasis pathogenesis may be the abnormal regulation of IL-23A and IL-1B genes in psoriatic keratinocytes. Key words: non-involved psoriatic epidermis; T-cell lymphokines; gene expression analysis; regulatory networks; IL-23A.

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