REAL

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition

Koivisto, Hennariikka and Grimm, Marcus O. and Rothhaar, Tatjana L. and Berkecz, Róbert and Lütjohann, Dieter and Giniatullina, Rajsa and Takalo, Mari and Miettinen, Pasi O. and Lahtinen, Hanna-Maija and Giniatullin, Rashid and Penke, Botond and Janáky, Tamás and Broersen, Laus M. and Hartmann, Tobias and Tanila, Heikki (2014) Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition. Journal of Nutritional Biochemistry, 25 (2). 157 - 169. ISSN 0955-2863, ESSN: 1873-4847

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Abstract

Abstract Dietary fish oil, providing n3 polyunsaturated fatty acids like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), associates with reduced dementia risk in epidemiological studies and reduced amyloid accumulation in Alzheimer mouse models. We now studied whether additional nutrients can improve the efficacy of fish oil in alleviating cognitive deficits and amyloid pathology in APPswe/PS1dE9 transgenic and wild-type mice. We compared four isocaloric (5 fat) diets. The fish oil diet differed from the control diet only by substituted fish oil. Besides fish oil, the plant sterol diet was supplemented with phytosterols, while the Fortasyn diet contained as supplements precursors and cofactors for membrane synthesis, viz. uridine-monophosphate; {DHA} and EPA; choline; folate; vitamins B6, B12, C and E; phospholipids and selenium. Mice began the special diets at 5 months and were sacrificed at 14 months after behavioral testing. Transgenic mice, fed with control chow, showed poor spatial learning, hyperactivity in exploring a novel cage and reduced preference to explore novel odors. All fish-oil-containing diets increased exploration of a novel odor over a familiar one. Only the Fortasyn diet alleviated the spatial learning deficit. None of the diets influenced hyperactivity in a new environment. Fish-oil-containing diets strongly inhibited β- and γ-secretase activity, and the plant sterol diet additionally reduced amyloid-β 1–42 levels. These data indicate that beneficial effects of fish oil on cognition in Alzheimer model mice can be enhanced by adding other specific nutrients, but this effect is not necessarily mediated via reduction of amyloid accumulation.

Item Type: Article
Uncontrolled Keywords: Phytosterol
Subjects: Q Science / természettudomány > QD Chemistry / kémia > QD01 Analytical chemistry / analitikai kémia
Depositing User: Dr. Róbert Berkecz
Date Deposited: 26 Sep 2014 07:52
Last Modified: 26 Sep 2014 20:38
URI: http://real.mtak.hu/id/eprint/17003

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