REAL

O-Arylation of Iodophenols with 2-Fluorobenzaldehyde Under Microwave Conditions

Bálint, Erika and Kallai, M. and Kovacs, O. and Bolcskei, H. and Keglevich, György (2014) O-Arylation of Iodophenols with 2-Fluorobenzaldehyde Under Microwave Conditions. LETTERS IN DRUG DESIGN AND DISCOVERY, 11 (1). pp. 114-120. ISSN 1570-1808

[img]
Preview
Text
O_arylation_of_iodophenols_u_135331.565698.pdf

Download (2MB) | Preview

Abstract

The arylation of 4-iodo-, 2-iodo- and 3-iodophenols with 2-fluorobenzaldehyde may be carried out in the presence of K2CO3 in DMF as the solvent under microwave conditions. The arylation of 4-iodophenole was promoted by the use of triethylbenzylammonium chloride (TEBAC) as the phase transfer catalyst. In the other model reactions, the use of TEBAC was harmful. By-products formed by isomerization and disproportionation were also detected.

Item Type: Article
Uncontrolled Keywords: ARYL; PHENOLS; ESTERIFICATION; ETHERS; IRRADIATION; C-ALKYLATION; ACTIVE METHYLENE; SOLVENT-FREE CONDITIONS; PHASE-TRANSFER CATALYSIS; phase transfer catalysis; microwave; arylation; Iodophenols; 2-Flourobenzaldehyde
Subjects: Q Science / természettudomány > QD Chemistry / kémia > QD04 Organic chemistry / szerves kémia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 05 Feb 2015 14:44
Last Modified: 31 Dec 2015 00:15
URI: http://real.mtak.hu/id/eprint/21284

Actions (login required)

Edit Item Edit Item