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A rational approach for generating cardiac troponin I selective Spiegelmers

Szeitner, Zsuzsanna and Lautner, Gergely and Nagy, K. Szilvia and Gyurcsányi, Ervin Róbert and Mészáros, Tamás (2014) A rational approach for generating cardiac troponin I selective Spiegelmers. Chemical Communications (50). pp. 6801-6804.

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Abstract

We report the first protein selective Spiegelmers of diagnostic relevance by rational identification of a target epitope and reverse screening of Spiegelmer candidates following the selection procedure. Application of the presented approach resulted in isolation of cardiac troponin I selective Spiegelmers with low nanomolar dissociation constant and functionality in serum.

Item Type: Article
Subjects: Q Science / természettudomány > Q1 Science (General) / természettudomány általában
Q Science / természettudomány > QD Chemistry / kémia
Q Science / természettudomány > QD Chemistry / kémia > QD01 Analytical chemistry / analitikai kémia
Q Science / természettudomány > QR Microbiology / mikrobiológia > QR180 Immunology / immunológia
Depositing User: Berényi Szilvia
Date Deposited: 12 Feb 2015 07:35
Last Modified: 13 Feb 2015 12:11
URI: http://real.mtak.hu/id/eprint/21583

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