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Possible role of fat tissue in the pharmacokinetics of dodeca-2E,4E,8Z,10E/ Z-tetraenoic acid isobutylamides after oral administration of Echinacea angustifolia extract in rats

Jedlinszki, Nikoletta and Rédei, Dóra and Haller, József and Freund, Tamás and Hohmann, Judit and Zupkó, István (2014) Possible role of fat tissue in the pharmacokinetics of dodeca-2E,4E,8Z,10E/ Z-tetraenoic acid isobutylamides after oral administration of Echinacea angustifolia extract in rats. NATURAL PRODUCT COMMUNICATIONS, 9 (6). pp. 843-845. ISSN 1934-578X

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Abstract

Alkamides are one of the most important constituents of lipophilic extracts of Echinacea angustifolia roots. These compounds play an important role in the versatile pharmacological actions of this plant. The present study aimed to compare the concentrations of isomeric dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (DTAI) in brain and periepididymal fat tissues and blood plasma of rats. Thirty, 60, 240 and 720 min after the oral administration of E. angustifolia root extract, tissue and plasma concentrations were determined by reversed-phase HPLC with ESI-MS/MS detection. The calculated terminal t 1/2 of the mixture of DTAI was 8.28 h, which indicates a relatively slow elimination. In the 0.5-4 h period the brain/plasma and fat/plasma concentration ratios were continuously above 3 and 18, respectively, followed by equilibrium at 12 h. Our results indicate substantial accumulation of alkamides in lipid-rich tissues, which presumably contributes to a maintained pharmacological action.

Item Type: Article
Uncontrolled Keywords: PHARMACOKINETICS; HPLC-MS/MS; Echinacea angustifolia; Dodeca-2E,4 E,8Z,10e/Z-tetraenoic acid isobutylamides; Alkamide
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 12 Feb 2015 13:23
Last Modified: 12 Feb 2015 13:23
URI: http://real.mtak.hu/id/eprint/21635

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