TRP Channels in the Skin

Tóth, Balázs István and Oláh, Attila and Szöllősi, Attila and Bíró, Tamás (2014) TRP Channels in the Skin. BRITISH JOURNAL OF PHARMACOLOGY, 171 (10). pp. 2568-2581. ISSN 0007-1188

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Abstract

Emerging evidence suggest that transient receptor potential (TRP) ion channels not only act as "polymodal cellular sensors" found on sensory neurons but are also functionally expressed by a multitude of non-neuronal cell types. This is especially true in the skin, one of the largest organs of the body, where they apparently are deeply involved in regulating various cutaneous functions both under physiological and pathophysiological conditions. In this review, we focus on introducing the roles of several cutaneous TRP channels in the regulation of e.g. the skin barrier, skin cell proliferation and differentiation, immune functions, etc. Moreover, we also detail the putative involvement of several TRP channels in the development of certain skin diseases and define future TRP channel-targeted therapeutic opportunities.

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