Tantos, Ágnes and Kalmar, L. and Tompa, Péter (2015) The role of structural disorder in cell cycle regulation, related clinical proteomics, disease development and drug targeting. EXPERT REVIEW OF PROTEOMICS, 12 (3). pp. 221-233. ISSN 1478-9450
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Abstract
Understanding the molecular mechanisms of the regulation of cell cycle is a central issue in molecular cell biology, due to its fundamental role in the existence of cells. The regulatory circuits that make decisions on when a cell should divide are very complex and particularly subtly balanced in eukaryotes, in which the harmony of many different cells in an organism is essential for life. Several hundred proteins are involved in these processes, and a great deal of studies attests that most of them have functionally relevant intrinsic structural disorder. Structural disorder imparts many functional advantages on these proteins, and we discuss it in detail that it is involved in all key steps from signaling through the cell membrane to regulating transcription of proteins that execute timely responses to an ever-changing environment. © Informa Uk, Ltd.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Eukaryota; review; proteomics; physical disease; nonhuman; Molecular Biology; human; genetic transcription; eukaryote; effector cell; Drug targeting; disease course; Cytology; Cell Membrane; cell cycle regulation; cell cycle checkpoint; Cell Cycle; cell cycle protein; SIGNAL TRANSDUCTION; protein disorder; Post-translational modification; Checkpoint; CELL-CYCLE; CANCER |
| Subjects: | Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3015 Molecular biology / molekuláris biológia |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 23 Jul 2015 21:00 |
| Last Modified: | 22 Jul 2016 23:15 |
| URI: | http://real.mtak.hu/id/eprint/25599 |
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