Stromal Expression of Heat-Shock Protein 27 Is Associated with Worse Clinical Outcome in Patients with Colorectal Cancer Lung Metastases

Multhoff, Gabriele and Schweiger, Thomas and Nikolowsky, Christoph and Starlinger, Patrick and Traxler, Denise and Zimmermann, Matthias and Birner, Peter and Hegedüs, Balazs and Dome, Balazs and Bergmann, Michael and Mildner, Michael and Klepetko, Walter and Hoetzenecker, Konrad and Ankersmit, Hendrik Jan (2015) Stromal Expression of Heat-Shock Protein 27 Is Associated with Worse Clinical Outcome in Patients with Colorectal Cancer Lung Metastases. PLOS ONE, 10 (3). e0120724. ISSN 1932-6203

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Abstract

Pulmonary metastases are common in patients with primary colorectal cancer (CRC). Heat- shock protein 27 (Hsp27) is upregulated in activated fibroblasts during wound healing and systemically elevated in various diseases. Cancer-associated fibroblasts (CAFs) are also thought to play a role as prognostic and predictive markers in various malignancies includ- ing CRC. Surprisingly, the expression of Hsp27 has never been assessed in CAFs. There- fore we aimed to investigate the expression level of Hsp27 in CAFs and its clinical implications in patients with CRC lung metastases.

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