Repository of the Academy's Library

Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics

Kövesdi, Erzsébet and Lückl, János and Bukovics, Péter and Farkas, Orsolya and Pál, József and Czeiter, Endre and Szellár, Dóra and Dóczi, Tamás and Komoly, Sámuel and Büki, András (2010) Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics. Acta Neurochirurgica, 152 (1). pp. 1-17. ISSN 0001-6268

[img] PDF (Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics)
5._Update_on_protein_biomarkers_in_traumatic_brain_injury_with_emphasis_on_clinical_use_in_adults_and_pediatrics.pdf
Restricted to Registered users only

Download (341Kb)

Abstract

Purpose This review summarizes protein biomarkers in mild and severe traumatic brain injury in adults and children and presents a strategy for conducting rationally designed clinical studies on biomarkers in head trauma. Methods We performed an electronic search of the National Library of Medicine’s MEDLINE and Biomedical Library of University of Pennsylvania database in March 2008 using a search heading of traumatic head injury and protein biomarkers. The search was focused especially on protein degradation products (spectrin breakdown product, c-tau, amyloid-β1–42) in the last 10 years, but recent data on “classical” markers (S-100B, neuron-specific enolase, etc.) were also examined. Results We identified 85 articles focusing on clinical use of biomarkers; 58 articles were prospective cohort studies with injury and/or outcome assessment. Conclusions We conclude that only S-100B in severe traumatic brain injury has consistently demonstrated the ability to predict injury and outcome in adults. The number of studies with protein degradation products is insufficient especially in the pediatric care. Cohort studies with welldefined end points and further neuroproteomic search for biomarkers in mild injury should be triggered. After critically reviewing the study designs, we found that large homogenous patient populations, consistent injury, and outcome measures prospectively determined cutoff values, and a combined use of different predictors should be considered in future studies.

Item Type: Article
Subjects: R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában
Depositing User: Dr. Péter Bukovics
Date Deposited: 27 Jan 2012 07:40
Last Modified: 02 Oct 2012 12:57
URI: http://real.mtak.hu/id/eprint/2770

Actions (login required)

View Item View Item