Comparison of Path Tracking Flat Control and Working Point Linearization Based Set Point Control of Tumor Growth with Angiogenic Inhibition

Drexler, Dániel András and Sápi, Johanna and Szeles, Annamária and Harmati, István and Kovács, Levente (2012) Comparison of Path Tracking Flat Control and Working Point Linearization Based Set Point Control of Tumor Growth with Angiogenic Inhibition. BULETINUL STIINTIFIC AL UNIVERSITATI POLITEHNICA DIN TIMISOARA ROMANIA SERIA AUTOMATICA SI CALCULATORAE = SCIENTIFIC BULLETIN OF POLITECHNICA UNIVERSITY OF TIMISOARA TRANSACTIONS ON AUTOMATIC CONTROL AND COMPUTER SCIENCE, 57 (71 (2). pp. 113-120. ISSN 1224-600X

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Abstract

Targeted molecular therapies (TMT) represent new perspectives in cancer treatment, fighting against the specific characteristic of the investigated tumor. Antiangiogenic therapy represents a specific TMT and its role is to stop the angiogenesis of the tumor, the process of forming new blood vessels; hence, to stop tumor growth. Proper control algorithms for tumor growth control with angiogenic inhibition are analyzed in the current article in order to find optimal therapeutic protocols. Two slightly different approaches are compared: nonlinear control by exact linearization with path tracking control, and linear control by working point linearization with set point control. The control strategies are compared in terms of the characteristics of the input signal (the inhibitor, drug intake) that is crucial if the therapy will be put into practice.

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