Aladzsity, István and Madách, Krisztina and Szilágyi, Agnes and Gál, János and Pénzes, István and Prohászka, Zoltán and Fust, George (2011) Analysis of the 8.1 ancestral MHC haplotype in severe, pneumonia-related sepsis. Clinical immunology (Orlando, Fla.), 139 (3). pp. 282-289. ISSN 1521-7035
Restricted to Registered users only
The most frequent Caucasian MHC haplotype, AH8.1 - associated with numerous immunopathological differences and certain autoimmune diseases - was recently linked to the delayed onset of bacterial colonization in cystic fibrosis. Based on this observation, we hypothesized that the carriers of AH8.1 have lower risk for a worse outcome in sepsis. AH8.1 carrier state was determined in 207 Caucasian patients with severe, pneumonia-related sepsis. Our data showed that in patients without chronic obstructive pulmonary disease (COPD), septic shock - a serious consequence of the bacterial infection - occurred significantly less frequently (OR=0.3383; 95% CI=0.1141-0.995; p=0.043) in carriers of AH8.1, than in non-carriers. According to the multivariate logistic regression analysis, this haplotype had an independent protective role against septic shock in all patients (OR=0.315; 95% CI=0.100-0.992; p=0.048), particularly in COPD-free patients (OR=0.117; 95% CI=0.025-0.554; p=0.007). These results indicate that AH8.1 may confer protection against the progression of bacterial infection, and this could explain, at least partially, its high frequency in the Caucasian population.
|Subjects:||R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában|
|Depositing User:||Prof Zoltán Prohászka|
|Date Deposited:||27 Jan 2012 08:25|
|Last Modified:||26 Sep 2012 10:58|
Actions (login required)