REAL

Aptasensors for viral diagnostics

Kieboom, Corné H. van den and Beek, Samantha L. van der and Mészáros, Tamás and Gyurcsányi, Ervin Róbert and Ferwerda, Gerben (2015) Aptasensors for viral diagnostics. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 74. pp. 58-67. ISSN 0165-9936

[img]
Preview
Text
1_s2.0_S0165993615002435_main_u.pdf

Download (1MB) | Preview

Abstract

Novel viral diagnostic tools need to be affordable, fast, accurate and easy to use with sensitivity and specificity equivalent or superior to current standards. At present, viral diagnostics are based on direct detection of viral components or indirect detection by measuring antibodies generated in response to viral infection. While sensitivity of detection and quantification are still important challenges, we expect major advances from new assay formats and synthetic binding molecules, such as aptamers. Compared to traditional antibody-based detection, aptamers could provide faster adaptation to continuously evolving virus strains and higher discriminating capacity between specific virus serotypes. Aptamers are very stable and easily modifiable, so are ideal molecules for detection and chemical sensing applications. Here, we review the use of aptasensors for detection of viral pathogens and consider the feasibility of aptasensors to become standard devices for point-of-care diagnostics of viruses. © 2015.

Item Type: Article
Uncontrolled Keywords: Chemical detection; serotypes; Sensitivity and Specificity; Point of care diagnostic; Indirect detection; Detection and quantifications; Chemical sensing applications; APTAMERS; VIRUSES; sensors; Plasma diagnostics; PATHOGENS; MOLECULES; Error detection; CHEMICAL SENSORS; ASSAYS; ANTIBODIES; VIRUS; serotype; SENSOR; Point of care; PATHOGEN; diagnostics; Detection; ASSAY; aptamer; ANTIBODY
Subjects: Q Science / természettudomány > QD Chemistry / kémia
Q Science / természettudomány > QR Microbiology / mikrobiológia > QR355 Virology / víruskutatás
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 21 Jan 2016 09:04
Last Modified: 31 Dec 2016 00:15
URI: http://real.mtak.hu/id/eprint/32536

Actions (login required)

Edit Item Edit Item