The design of multitarget ligands for chronic and neuropathic pain

Dvorácskó, Szabolcs and Stefanucci, Azzurra and Novellino, Ettore and Mollica, Adriano (2015) The design of multitarget ligands for chronic and neuropathic pain. Future Medicinal Chemistry, 7 (18). pp. 2469-2483. ISSN 1756-8919

[img] Text
Restricted to Registered users only

Download (384kB)


Background: Monodrug therapy has been used with success to fight various pathologies. When one medicine fails, co-administration of two or more drugs at the same time may be successfully applied in the treatment of infections, hypertension, HIV and in many other fields. Discussion: This approach has some weakness related to the pharmacokinetic of the two different substances administered, side effects, possible drug-drug interaction. Bivalent ligand approach would maintain the strength of the multidrug therapy (synergistic effect, lower doses, and little side effects) and overcome the weakness of a co-administration. Conclusion: In this review we have described the state-of-the-art of the multitarget approach for the control of pain. Several approaches adopted by different research groups and future perspectives have been discussed. © 2015 Future Science Ltd.

Item Type: Article
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3011 Biochemistry / biokémia
R Medicine / orvostudomány > RM Therapeutics. Pharmacology / terápia, gyógyszertan
Depositing User: MTMT SWORD
Date Deposited: 10 Feb 2016 12:23
Last Modified: 10 Feb 2016 12:23

Actions (login required)

Edit Item Edit Item