Tóth, Eszter and Vékey, Károly and Ozohanics, Olivér and Jekő, Anita and Dominczyk, Iwona and Widlak, Piotr and Drahos, László (2016) Changes of protein glycosylation in the course of radiotherapy. Journal of Pharmaceutical and Biomedical Analysis, 118. pp. 380-386. ISSN 0731-7085 (Submitted)
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Abstract
This is the first study of changes in protein glycosylation due to exposure of human subjects to ionizing radiation. Site specific glycosylation patterns of 7 major plasma proteins were analyzed; 171 glycoforms were identified; and the abundance of 99 of these was followed in the course of cancer radiotherapy in 10 individual patients. It was found that glycosylation of plasma proteins does change in response to partial body irradiation (~60 Gy), and the effects last during follow-up; the abundance of some glycoforms changed more than twofold. Both the degree of changes and their time-evolution showed large inter-individual variability.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science / természettudomány > QD Chemistry / kémia > QD01 Analytical chemistry / analitikai kémia |
| Depositing User: | Eszter Tóth |
| Date Deposited: | 29 Mar 2016 14:09 |
| Last Modified: | 29 Mar 2016 14:13 |
| URI: | http://real.mtak.hu/id/eprint/34511 |
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