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Epidemiological and pathological features of primary cardiac tumours in dogs from Poland in 1970–2014

Janus, Izabela and Nowak, Marcin and Noszczyk-Nowak, Agnieszka and Ciaputa, Rafał and Kandefer-Gola, Małgorzata and Pasławska, Urszula and Sapierzyński, Rafał and Łopuszyński, Wojciech and Otrocka-Domagała, Iwona (2016) Epidemiological and pathological features of primary cardiac tumours in dogs from Poland in 1970–2014. Acta Veterinaria Hungarica, 64 (1). pp. 90-102. ISSN 0236-6290

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Abstract

Primary heart tumours affect less than 1% of dogs. Due to their rare incidence, every research showing the frequency of cardiac tumours is valuable. Routine diagnostics is often complemented with immunohistochemical analysis. This study was conducted on 110 patient records from all veterinary faculties in Poland from dogs diagnosed with heart tumours between 1970 and 2014. The dogs’ age, breed and sex with tumour localisation and histopathological diagnosis were analysed. Because of its most common incidence, samples of haemangiosarcoma underwent further examination with assessment of the expression of cell markers that have not been evaluated earlier (i.e. minichromosome maintenance proteins and beta-catenin). We noted 111 tumours including 88.3% malignant and 10.8% benign ones. Haemangiosarcoma and aortic body tumour were the most frequent cardiac neoplasms in the dogs examined (45.9% and 27.9% of all tumours, respectively). Immunohistochemical analysis of haemangiosarcoma showed a positive expression of all markers examined. CD31, vimentin, and beta-catenin showed a positive reaction in all 11 samples examined. At least one proliferative marker (Ki-67, MCM-3 or MCM-7) showed a positive reaction in each sample. MCM-3 showed a higher expression than the two other proliferative markers (P = 0.006), but only Ki-67 showed a positive correlation with the mitotic index (P > 0.05, r = 0.89). Although beta-catenin, MCM-3 and MCM-7 showed a positive reaction in the haemangiosarcomas examined, their usefulness as diagnostic and prognostic factors should be a topic of further research.

Item Type: Article
Subjects: S Agriculture / mezőgazdaság > SV Veterinary science / állatorvostudomány
Depositing User: Erika Bilicsi
Date Deposited: 02 Jun 2016 04:29
Last Modified: 31 Mar 2017 23:15
URI: http://real.mtak.hu/id/eprint/35579

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