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Location and age at onset of colorectal cancer in Hungarian patients between 1993 and 2004. The high number of advanced cases supports the need for a colorectal cancer screening program in Hungary

Fuszek, Péter and Horváth, Henrik Csaba and Speer, Gábor and Papp, János and Haller, Petra and Fischer, Simon and Halász, Judit and Járay, Balázs and Székely, Eszter and Schaff, Zsuzsa and Papp, Andreas and Bursics, Attila and Harsányi, László and Lukovich, Péter and Kupcsulik, Péter and Hitre, Erika and Lakatos, Péter László (2006) Location and age at onset of colorectal cancer in Hungarian patients between 1993 and 2004. The high number of advanced cases supports the need for a colorectal cancer screening program in Hungary. Anticancer Research, 26 (1B). pp. 527-531. ISSN 0250-7005 (print), 1791-7530 (online)

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Abstract

Background: In recent decades, the incidence of proximal colorectal cancer (CRC) in North America and Western Europe has steadily increased, while that of the distal tumors has shown a corresponding decrease. Our aim was to investigate the change in age at diagnosis, the gender, location and cancer stage of CRC cases over the last 12 years in a large number of Hungarian patients. Patients and Methods: The clinical and histological data of 1694 CRC patients (M/F:917/777, age at diagnosis: 65.2 +/- SD 12.5 years), diagnosed at the First Department of Medicine and the First Department of Surgery of Semmelweis University, Budapest, Hungary, between January 1, 1993 and December 31, 2004, were analyzed retrospectively. Results: CRCs were rectal or left-sided in 70% and proximal (transverse, ascending or cecum) in 30% of the cases. The proportion of rectal carcinomas increased over the observed period (1993-1998: 31.6% vs. 1999-2004: 42.1%, p = 0.001), while the proportion of proximal tumors remained stable. Eleven percent of CRCs were diagnosed under the age of 50 years. The age at diagnosis did not differ between males and females, but was lower in patients with rectal tumors compared to other localizations (p = 0.02); 75.7% of the CRCs were T3-T4 at diagnosis and lymph node metastases could be detected in 47.7%. Conclusion: In contrast to Western European and North American trends, the proportion of proximal CRCs did not increase in Hungary over the observed period. Almost two-thirds of all cancers were left-sided. The high percentage of locally advanced tumors and lymph node metastases supports the need for colorectal screening programs.

Item Type: Article
Uncontrolled Keywords: colorectal cancer; cancer screening
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat
R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0254 Neoplasms. Tumors. Oncology (including Cancer) / daganatok, tumorok, onkológia
Depositing User: Erika Bilicsi
Date Deposited: 19 Dec 2012 10:50
Last Modified: 19 Dec 2012 10:50
URI: http://real.mtak.hu/id/eprint/3642

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