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Clinical presentation of Crohn's disease. Association between familial disease, smoking, disease phenotype, extraintestinal manifestations and need for surgery

Lakatos, Péter László and Szalay, Ferenc and Tulassay, Zsolt and Molnár, Tamás and Kovács, Ágota and Gasztonyi, Beáta and Papp, János and Lakatos, László (2005) Clinical presentation of Crohn's disease. Association between familial disease, smoking, disease phenotype, extraintestinal manifestations and need for surgery. Hepato-Gastroenteorology, 52 (63). pp. 817-822. ISSN 0172-6390

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Abstract

Background/Aims: Recent molecular data suggest that genetic factors may underlie the disease heterogeneity observed in Crohn's disease (CD). It was also suggested that familial inflammatory bowel disease (IBD) is a homogenous subgroup, phenotypically different from sporadic disease. Our aim was to determine the clinical presentation in a large CD population. Methodology: 564 CD patients (m/f: 278/286, age: 37.4 (SD 12.7) yrs, duration: 8.4 (7.1) yrs) were included. Disease phenotype was determined according to Vienna classification. Familial disease, extraintestinal manifestations (EIM), need for surgery and smoking habits were also analyzed. Results: Familial IBD was present in 73 (12.9%) patients. Age at onset and presence of EIMs was associated with familial disease. Penetrating (44.6% vs. < 10yrs: 29.1%, P < 0.0001) and ileocolonic disease (54.4% vs. 42.8%, P=0.03) were more common in patients with a disease duration of >= 10yrs. In a logistic regression model female gender, colonic/ileocolonic location, smoking and familial IBD were independent risk factors for EIMs, while ileal and non-inflammatory disease increased the risk for resections. Smoking was also associated with frequent relapses. Conclusions: Familial IBD was associated with the presence of EIMs, while ileal involvement and noninflammatory behavior independently increased the risk for surgery. Since penetrating and extensive disease was more frequent in patients with longer disease duration our data support a possible change in location and behavior during the course of disease.

Item Type: Article
Uncontrolled Keywords: IBD; Crohn's disease; phenotype; familial; Zala Megyei Kórház tudományos közleményei
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat
Depositing User: Erika Bilicsi
Date Deposited: 19 Dec 2012 14:22
Last Modified: 05 Aug 2014 09:33
URI: http://real.mtak.hu/id/eprint/3648

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