Haptoglobin Polymorphisms Are Associated with Crohn’s Disease, Disease Behavior, and Extraintestinal Manifestations in Hungarian Patients

Papp, Mária and Lakatos, Péter László and Palatka, Károly and Földi, Ildikó and Udvardy, Miklós and Hársfalvi, Jolán and Tornai, István and Vitalis, Zsuzsanna and Dinya, Tamás and Kovács, Ágota and Molnár, Tamás and Demeter, Pál and Papp, János and Lakatos, László and Altorjay, István (2007) Haptoglobin Polymorphisms Are Associated with Crohn’s Disease, Disease Behavior, and Extraintestinal Manifestations in Hungarian Patients. Digestive Diseases and Sciences, 52 (5). pp. 1279-1284. ISSN 0163-2116 (print), 1573-2568 (online)

PDF 1077488.pdf Restricted to Registered users only Download (194kB) | Request a copy

Abstract

Functional differences and association with inflammatory disorders were found relating to three major haptoglobin (Hp) phenotypes. Our aim was to investigate Hp polymorphisms in Hungarian patients with Crohn's disease (CD). Four hundred sixty-eight CD patients and 384 healthy controls were examined. Hp phenotypes were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting of the sera. The frequency of the Hp(1) allele was significantly higher in CD (0.395; OR, 1.24; 95% CI, 1.02-1.52; P=0.03) compared to controls (0.345). In CD, Hp phenotype was associated with disease behavior (OR [Hp(2-1) vs other], 2.06; 95% CI, 1.29-3.28 for inflammatory behavior). Furthermore, an increased frequency of primary sclerosing cholangitis was observed in the Hp 2-2 compared to the Hp 1-1 phenotype (6.5% vs. 0.0%; P=0.039). We conclude that the Hp polymorphism is associated with CD, inflammatory disease behavior, and primary sclerosing cholangitis in Hungarian patients. Further studies are required to evaluate the significance of Hp polymorphisms in other populations from geographically diverse regions.

Actions (login required)

Edit Item