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Oral administration of fumonisin B1 and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits

Szabó, András and Szabó-Fodor, Judit and Fébel, Hedvig and Mézes, Miklós and Bajzik, Gábor and Kovács, Melinda (2016) Oral administration of fumonisin B1 and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits. Acta Physiologica Hungarica. pp. 1-19. ISSN 0231-424X (Submitted)

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Abstract

Weaned rabbits were fed diets contaminated with 2 mg/kg diet T-2 toxin alone, or 10 mg/kg diet fumonisin B1 (FB1) alone, and both toxins in combination (2+10 mg / kg, resp.), as compared to a toxin free control diet. Samplings were performed after 4 weeks (blood and liver). Bodyweight of T-2-fed group was lower after 4 weeks; the liver weight was increased dramatically (3-fold of control). Liver total phospholipids (PL) provided slight alterations in the fatty acid (FA) composition; all three toxin treated groups showed decrease in palmitoleic acid (C16:1 n7) proportion. In the liver mitochondrial PL FA composition margaric acid (C17:0) proportion decreased in the separated toxin treatments, compared to the combined setting. Oleic acid (C18:1 n9) proportion was increased and arachidonic acid (C20:4 n6) was decreased in the by FB1-treated group, while docosapentaenoic acid (C22:5 n3) was decreased in the separated treatments. The total monounsaturation was significantly higher in the FB1 group’s mitochondrial PL FA profile. After 4 weeks, all toxin treatments decreased the blood plasma reduced glutathione and glutathione peroxidase activity, and FB1 increased the plasma sphinganine/sphingosine ratio. Both mycotoxins seem to cross the hepatocellular and the hepatic mitochondrial membrane, without drastic membrane disruption, as assessed from the PL FA composition, but inducing detectable lipid peroxidation.

Item Type: Article
Subjects: S Agriculture / mezőgazdaság > SV Veterinary science / állatorvostudomány
Depositing User: Diszterhöft Zoltán
Date Deposited: 27 Sep 2016 09:08
Last Modified: 27 Sep 2016 09:08
URI: http://real.mtak.hu/id/eprint/40158

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