Design, realisation and validation of microfluidic stochastic mixers integrable in bioanalytical systems using CFD modeling

Leelőssyné Tóth, Eszter and Iván, Kristóf and Fürjes, Péter and Fekete, Zoltán and Holczer, Eszter Gabriella (2013) Design, realisation and validation of microfluidic stochastic mixers integrable in bioanalytical systems using CFD modeling. In: 2013 IEEE Biomedical Circuits and Systems Conference (BioCAS). IEEE, Piscataway, NJ, pp. 266-269. ISBN 978-1-4799-1469-2

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In this work we present the design aspects of special microfluidic structures applicable to dilute and transport analyte solutions (such as whole blood) to the sensing area of biosensors. Our goal is to design and realise a reliable microfluidic system which is applicable for effective sample transport and can accomplish simple sample preparation functions such as mixing to ensure homogeneous concentration distribution of the species along the fluidic channel. The behaviour of different chaotic mixers were analysed by numerical modeling and experimentally to determine their efficiency. At first we used the concentration distribution method, however because of numerical diffusion this required higher mesh resolutions. Using the particle tracing method is more efficient according to the experimental results and requires lower computational effort. The microstructures were realised by micro-fabrication in polydimethylsiloxane (PDMS) and integrated into a real microfluidic transport system. The functional performance was verified by biological analyte.

Item Type: Book Section
Uncontrolled Keywords: whole blood; transport analyte solution; simple sample preparation function; Resists; reliable microfluidic system; real microfluidic transport system; POLYMERS; polymer microfluidics; POLYDIMETHYLSILOXANE; PDMS; particle tracing method; Numerical models; Numerical modeling; numerical diffusion; Mixing; Mixers; Microstructure; Microsensors; micromixers; Microfluidics; microfluidic structure; microfluidic stochastic mixer; MICROFABRICATION; microchannel flow; mesh resolutions; Mesh generation; mathematical model; lab-on-a-chip; homogeneous concentration distribution; FUNCTIONAL PERFORMANCE; fluidic channel; dilute analyte solution; Design aspects; concentration distribution method; Computational modeling; computational fluid dynamics (CFD); Computational fluid dynamics; Computational effort; chaotic mixers; chaotic advection; CFD modeling; biosensors; biosensor sensing area; bioMEMS; biological analyte; biodiffusion; Bioanalytical systems
Subjects: Q Science / természettudomány > Q1 Science (General) / természettudomány általában
Q Science / természettudomány > QA Mathematics / matematika > QA75 Electronic computers. Computer science / számítástechnika, számítógéptudomány
Depositing User: MTMT SWORD
Date Deposited: 02 Jan 2017 08:12
Last Modified: 02 Jan 2017 08:12

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