Childhood acute lymphoblastic leukaemia in relation to population mixing around the time of birth in South Hungary

Nyári, Tibor András and Kajtár, Pál and Bartyik, Katalin and Thurzó, László and Parker, Louise (2006) Childhood acute lymphoblastic leukaemia in relation to population mixing around the time of birth in South Hungary. Pediatric Blood and Cancer, 47 (7). pp. 944-948. ISSN 1545-5009

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Abstract

In a retrospective epidemiological study of 481,984 live births in South Hungary, we investigated whether higher levels of population mixing around the time of birth is a risk factor for acute lymphoblastic leukemia (ALL) under age 5 years. Poisson regression was used to investigate the relationship between risk of ALL and the population-mixing index based on the number of incomers in each county district for each year, standardized to have a range of 0-1. Among all children, the risk of ALL increased significantly with increasing population mixing around the time of birth (trend across the range of 0-1 RR = 2.1 95% CI: 1.02-4.44). This effect was more marked for boys (RR=3.1 95% CI: 1.13-8.51), which supports a sex-specific effect of exposures on risk of ALL.

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