Antibiotic susceptibility profiles of Mycoplasma sp. 1220 strains isolated from geese in Hungary

Grózner, Dénes and Kreizinger, Zsuzsa and Sulyok, Kinga Mária and Rónai, Zsuzsanna and Hrivnák, V. and Turcsányi, Ibolya and Jánosi, Szilárd and Gyuranecz, Miklós (2016) Antibiotic susceptibility profiles of Mycoplasma sp. 1220 strains isolated from geese in Hungary. BMC VETERINARY RESEARCH, 12. p. 170. ISSN 1746-6148

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Abstract

Background: Mycoplasma sp. 1220 can induce inflammation primarily in the genital and respiratory tracts of waterfowl, leading to serious economic losses. Adequate housing and appropriate antibiotic treatment are promoted in the control of the disease. The aim of the present study was to determine the in vitro susceptibility to thirteen different antibiotics and an antibiotic combination of thirty-eight M . sp. 1220 strains isolated from geese and a duck in several parts of Hungary, Central Europe between 2011 and 2015. Results: High MIC 50 values were observed in the cases of tilmicosin (>64 μ g/ml), oxytetracycline (64 μ g/ml), norfloxacin (>10 μ g/ml) and difloxacin (10 μ g/ml). The examined strains yielded the same MIC 50 values with spectinomycin, tylosin and florfenicol (8 μ g/ml), while enrofloxacin (MIC 50 5 μ g/ml), doxycycline (MIC 50 5 μ g/ml), lincomycin (MIC 50 4 μ g/ml) and lincomycin-spectinomycin (1:2) combination (MIC 50 4 μ g/ml) inhibited the growth of the bacteria with lower concentrations. Tylvalosin (MIC 50 0.5 μ g/ml) and two pleuromutilins (tiamulin MIC 50 0. 625 μ g/ml; valnemulin MIC 50 ≤ 0.039 μ g/ml) were found to be the most effective drugs against M . sp. 1220. However, strains with elevated MIC values were detected for all applied antibiotics. Conclusions: Valnemulin, tiamulin and tylvalosin were found to be the most effective antibiotics in the study. Increasing resistance was observed in the cases of several antibiotics. The results highlight the importance of testing Mycoplasma species for antibiotic susceptibility before therapy.

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