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Neuroinvasive influenza virus A(H5N8) in fattening ducks, Hungary, 2015

Bányai, Krisztián and Tóthné Bistyák, Andrea and Thuma, Ákos and Gyuris, Éva and Ursu, Krisztina and Marton, Szilvia and Farkas, Szilvia L. and Hortobágyi, Eleonóra and Bacsadi, Árpád and Dán, Ádám (2016) Neuroinvasive influenza virus A(H5N8) in fattening ducks, Hungary, 2015. INFECTION, GENETICS AND EVOLUTION (43). pp. 418-423. ISSN 1567-1348

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Abstract

Highly pathogenic avian in fl uenza (HPAI) A virus H5N8 was detected in far east Asian countries during 2014 and emerged in late 2014 in European countries. Hungary reported a HPAI A(H5N8) outbreak during late winter of 2015 at a Pekin duck fattening facility. Epidemiologic monitoring was extended to holdings in neighboring areas and nearby habitats used by wild birds but failed to identify the source of infection. In addition to respira- tory symptoms, the affected birds showed lethargy and neuronal signs, including torticollis. Consistent with this fi nding, in fl uenza A virus antigen was detected in large quantity in the brain. Molecular analysis of the identi fi ed strain showed very close genetic relationship (and N 99% nucleotide sequence identity) with co-circulating HPAI A(H5N8) strains. A number of unique or rarely detected amino acid changes was detected in the HA (T220I, R512G), the M2 (I39M), the NA (T211I), the NS1 (P85T), and the PB2 (I261V) proteins of the Hungarian strain. Further studies are needed to demonstrate whether any of these mutations can be linked to neuroinvasiveness and neurovirulence in ducks.

Item Type: Article
Subjects: Q Science / természettudomány > QR Microbiology / mikrobiológia > QR355 Virology / víruskutatás
Depositing User: Dr. Szilvia Farkas
Date Deposited: 20 Jan 2017 22:34
Last Modified: 20 Jan 2017 22:34
URI: http://real.mtak.hu/id/eprint/46106

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