Gyertyán, István (2017) Cognitive "Omics": Pattern-based Validation of Potential Drug Targets. TRENDS IN PHARMACOLOGICAL SCIENCES, 38 (2). pp. 113-126. ISSN 0165-6147
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Abstract
Despite the abundance of cognitive enhancer mechanisms identified in basic research,drugs approved for cognitive disorders are scarce and of limited efficacy. Although the so called „gold standard" animal assays are well suited to study fundamental learning processes they fail to predict clinical efficacy against complex and robust cognitive defects. Preclinical validation of potential drug targets requires new approaches with higher translational value. In a rodent cognitive test system proposed in this article several learning paradigms are used, each modelling a certain human cognitive domain. Cognitive deficits are brought about by several impairing methods and a particular mechanism of action is tested on each defective cognitive function. The outcome is a cognitive efficacy pattern which should then be matched to the cognitive deficit patterns of the clinical disorders. The best fit will highlight the clinical indication with the greatest chance for success.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria |
| Depositing User: | Dr. István Gyertyán |
| Date Deposited: | 23 Jan 2017 09:07 |
| Last Modified: | 02 Feb 2018 00:15 |
| URI: | http://real.mtak.hu/id/eprint/46110 |
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